This report reviews the activities, accomplishments, and disappointments of the Maine Indian Tribal-State Commission (MITSC) during the year 2000. After introductory information in Section 1, the report’s next five sections describe what happened during the year 2000. Section 2 provides an overview of MITSC’s members, meetings, and process; Section 3 reviews key pieces of legislation; Section 4 describes MITSC’s education activities; Section 5 summarizes the major natural resources and environmental issues before MITSC; and Section 6 analyses the tribal-state relations process. Based on what has happened during the year 2000, Section 7 identifies proposed areas of focus for the year 2001.